ribociclib will increase the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
If coadministration of CYP3A4 inhibitors with fentanyl is critical, watch patients for respiratory depression and sedation at Recurrent intervals and consider fentanyl dose adjustments until finally stable drug effects are attained.
drospirenone will increase the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Unknown.
Monitor Intently (one)somatrogon will reduce the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
fentanyl will raise the level or effect of avapritinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
Watch Intently (1)pentobarbital will decrease the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Intently. Coadministration of fentanyl with CYP3A4 inducers could lead on to some lower in fentanyl plasma concentrations, not enough efficacy or, maybe, growth of a withdrawal syndrome in a very individual who may have produced Bodily dependence to fentanyl. After halting a CYP3A4 inducer, as the effects with the inducer decline, the fentanyl plasma concentration will improve which could maximize or prolong the two the therapeutic and adverse effects.
fentanyl will boost the level or effect of isavuconazonium sulfate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
buprenorphine buccal decreases effects of fentanyl by pharmacodynamic antagonism. Steer clear of or Use Alternate Drug. Coadministration of mixed agonist/antagonist and partial agonist opioid analgesics may possibly lessen fentanyl's analgesic effect and possibly precipitate withdrawal symptoms.
If your patch is missing, make positive it hasn't stuck to some other person's skin, Particularly a Kid's, by mistake – for instance if it falls off in mattress fentanyl education in schools or if the patch falls on the floor.
Keep an eye on Intently (1)bosentan will reduce the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Closely. Coadministration of fentanyl with CYP3A4 inducers could lead to some lessen in fentanyl plasma concentrations, insufficient efficacy or, quite possibly, advancement of a withdrawal syndrome in a client who's got produced Actual physical dependence to fentanyl.
omaveloxolone will lower the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Omaveloxolone could cut down systemic exposure of delicate CYP3A4 substrates. Examine prescribing information of substrate if dosage modification is needed.
Monitor Closely (one)rifabutin will lower the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Carefully. Coadministration of fentanyl with CYP3A4 inducers may lead to your decrease in fentanyl plasma concentrations, insufficient efficacy or, maybe, growth of a withdrawal syndrome in a very affected person that has designed Actual physical dependence to fentanyl.
fentanyl will raise the level or effect of lemborexant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Intently. Lessen nightly dose of lemborexant encouraged if coadministered with weak CYP3A4 inhibitors. See drug monograph for distinct dosage modification.
fentanyl and fentanyl iontophoretic transdermal system both equally increase sedation. Stay away from or Use Alternate Drug. Restrict use to patients for whom alternate treatment options are inadequate